The invention relates to a device (1) for disintegrating particles (3) of a suspension with ultrasonic sound. The device (1) comprises a channel (10) for a suspension, wherein the channel (10) comprises a particle processing portion (12). Furthermore, the device (1) comprises at least one pump (20) configured and arranged to adjust a flow velocity of the suspension in the channel (10), and at least one ultrasonic sound source (30), which is arranged such at the channel that an ultrasonic field generated by the ultrasonic sound source (30) extends at least in the particle-processing portion (12) inside the channel (10). The device (1) is configured such that particles (3) of the suspension are arrangeable in a predefined spatial particle distribution in the particle-processing portion (12) of the channel (10) by adjusting the flow velocity of the suspension with respect to an inertial force (40) acting on the suspension, wherein the inertial force (40) is gravity (42) or a centrifugal force (44).